Fighting against one's true desires is a difficult struggle because these inner wishes often compel individuals to pursue their goals regardless of the consequences. The quote suggests that succumbing to these desires can come at a significant personal cost, potentially sacrificing one's moral integrity or soul.

According to Lawrence Durrell in his book Justine, the heart's desires are powerful and sometimes irresistible, driving people to make choices they might later regret. It emphasizes the internal conflict between the pursuit of personal wishes and maintaining one's ethical self, highlighting the sacrifices involved in following one’s true passions.