The concept of mindfulness regarding the transient nature of existence, or impermanence, serves as a fundamental entry point in spiritual practice. Recognizing anicca, or impermanence, is essential for progressing in meditation and mindfulness. This awareness helps practitioners confront the nature of suffering (dukkha) and the lack of a permanent self (anatta), which are also core aspects of understanding reality.

Through the contemplation of these three characteristics—anicca, dukkha, and anatta—individuals can move toward liberation. The insights gained from acknowledging their interconnectedness pave the way for deeper states of meditation, as highlighted in 'Beyond Mindfulness in Plain English' by Henepola Gunaratana. Overall, this process encourages a profound transformation in one’s perception of life and suffering.