William Styron, in "Darkness Visible: A Memoir of Madness," explores the intense despair experienced by individuals with depression. He describes how these individuals often find themselves in a state of extreme hopelessness, perceiving exaggerated threats and suffering that do not align with reality. This distorted perspective creates a deep sense of worthlessness, making it difficult for them to see the value of their own existence.

Styron emphasizes the critical role of loved ones in helping those afflicted with depression. It often takes immense emotional support and dedication from friends and family to counteract the bleak views held by the depressed. This unwavering devotion can be vital in reminding them of life's worth and can be a lifesaving force that has saved many from considering suicide.