In Samuel Beckett's "Waiting for Godot," the quote "We are all born crazy. Some remain" encapsulates the theme of existential absurdity that permeates the play. It suggests that human beings enter the world with a sense of madness or irrationality, a characteristic that may persist into adulthood for some individuals. This reflects a fundamental aspect of human nature and the unpredictability of life, as characters grapple with their existence and the meaning of waiting.

The notion of remaining 'crazy' can also be interpreted as a commentary on societal norms and the pressures to conform. In the play, the characters find themselves in a state of limbo, constantly waiting for something that never arrives. This waiting can drive individuals to embrace or reject their inherent madness, leading to a profound exploration of sanity, purpose, and the human condition within an indifferent universe.