Mindy Kaling's quote from "Why Not Me?" emphasizes the challenges of building and maintaining relationships. While gaining someone's affection can be a tough endeavor, sustaining that liking over time proves to be an even greater challenge. This highlights the complexities of social interactions and the effort required to nurture connections with others.

The struggle to be liked and to stay likable underscores the importance of authenticity, kindness, and understanding in relationships. Kaling's reflection serves as a reminder that while initial impressions hold weight, it is the continuous work on friendships and relationships that truly matters in the long run.