In "The 42nd Parallel," John Dos Passos presents a bold vision for the twentieth century, predicting that American influence will shape the era's thoughts, progress, and achievements. He emphasizes that the leaders in innovation and civilization will arise from the United States, asserting that its advancements will color the world and leave a lasting impact on societies. Dos Passos paints a picture of a world where American ideals and actions will inspire and uplift global civilization.

The author also highlights the transformative power of modernity, suggesting that cities like Shanghai and Hong Kong will remain centers of civilization and connectivity. He expresses a belief that China's historical barriers will be dismantled, allowing for the integration of modern ideas and practices. Dos Passos concludes that the world's moral and physical regeneration is underway, indicating that societal change is inevitable and progress is forward-moving, never reverting to the past.