In "On Every Side" by Karen Kingsbury, the narrative explores themes of resilience and hope amidst life's challenges. The characters face various troubles and adversities, reflecting the struggles people often encounter in the world. These experiences serve as a backdrop for their journeys toward understanding and overcoming their obstacles.

The book emphasizes a powerful message drawn from the quote, "In this world you will have trouble. But take heart! I have overcome the world." This encapsulates the idea that despite facing difficulties, there is a greater strength that can help individuals navigate through their struggles. Kingsbury inspires readers to find courage and faith in the face of hardships.