Ted Cruz emphasizes that the most significant threat to U.S. national security today is the possibility of Iran developing nuclear weapons. He highlights the fact that the Iranian leadership, driven by extreme religious beliefs, has openly declared its intentions to destroy Israel and expresses hostility towards the United States. This situation creates a severe risk, as a nuclear-armed Iran could potentially cause mass casualties among Americans and allied nations.

Cruz's perspective underscores the urgency in addressing this threat, suggesting that the consequences of a nuclear Iran could be catastrophic. He frames the issue not only in terms of military risk but also as a moral imperative for the U.S. and its allies to prevent such a situation from arising, given the intentions of the current Iranian regime.