In John Scalzi's "The Ghost Brigades," the narrative explores the theme of fairness in a universe that seems inherently unfair. The characters grapple with the harsh realities of their existence, which challenges their understanding of justice and morality. This sentiment is encapsulated in the quote, "We're in the wrong universe for fair," highlighting the cosmic indifference that often shapes their struggles. The story reflects on the idea that fairness may be an elusive concept in a vast and chaotic universe.

The characters’ experiences illustrate the disparity between their expectations and the actual challenges they face. Scalzi uses this reflection to delve into deeper philosophical questions regarding fate and personal choice amidst overwhelming odds. This tension serves as a driving force in the plot, prompting readers to consider how individuals navigate their paths in a universe where fairness is not guaranteed.