In Joyce Carol Oates' "American Appetites," the character Ian McCullough grapples with the complex nature of destiny. His perceptions of destiny fluctuate based on his emotional state, reflecting a deep ambiguity about what destiny truly signifies. He contemplates whether it is a mechanical fact of life, a mere theoretical idea, a concept shaped by human thought, or even a superstition devoid of real meaning.

The text portrays destiny as a contrasting concept to fate, suggesting that while fate may imply inevitability and tragedy, destiny could represent more hopeful or benign prospects. This duality prompts Ian to reflect on the significance of destiny in his own life, a theme that resonates throughout the narrative, inviting readers to ponder their own beliefs about the forces that shape human existence.