The quote emphasizes the transformation brought about by a profound realization of impermanence in life. It suggests that when one truly sees and experiences the transient nature of all conditioned things, a significant shift occurs in their mental state. This goes beyond a mere intellectual grasp of the concept, as it involves a deep, intuitive understanding that reshapes one's perception. Such insight is crucial in meditation, guiding practitioners toward deeper states of awareness.

This change in perception is highlighted as a pathway to achieving stream-entry, a state in Buddhist practice indicative of an initial breakthrough in understanding and spiritual development. By moving from a superficial acknowledgment of impermanence to a deep experiential awareness, individuals progress on their spiritual journey, gaining wisdom that transforms their outlook on existence and suffering.