In Stacy Schiff's "Cleopatra," the author contemplates the unpredictable nature of fate and how dramatically circumstances can shift in human life. The statement reflects a sense of wonder and incredulity regarding the unforeseen events that shape our destinies. It emphasizes the complexity and often baffling nature of fortune's whims.

The quote speaks to the universal experience of surprise at life's twists and turns, suggesting that no one can fully articulate the depths of this astonishment. Through Cleopatra's story, Schiff invites readers to explore the intricate dance between fortune and misfortune, revealing how these forces influence individuals and their journeys.