In Jonathan Lethem's "Men and Cartoons," the phrase "Yeah, maybe you look a little less familiar yourself" reflects a moment of introspection and alienation. This quote suggests that the characters are experiencing a shift in their perception of self and others, highlighting the theme of identity and the discomfort that arises from changes in personal connections.

The narrative delves into the complexities of human relationships in a world where familiarity often gives way to estrangement. Lethem explores how our understanding of identity can evolve, and how these transformations influence our interactions with those around us, leading to feelings of uncertainty and detachment.