The quote expresses a sense of false security that comes with companionship, suggesting that being with another person can feel reassuring. However, the speaker acknowledges that this comfort can be misleading, as the connection with "Thou" is unstable. Trusting someone completely might lead to disappointment when that person either disappears or betrays you.

The mention of individuals disappearing or proving untrustworthy highlights the unreliable nature of relationships. The speaker reflects on experiences with others who have left or let them down, emphasizing a deeper sense of vulnerability when relying on others. This sentiment suggests that while we may seek solace in companionship, we must also confront the potential for loss and betrayal.