As people age, they often experience feelings of melancholy and irritability, suggesting that getting older is closely tied to a decline in mood. Upon reaching middle age, one may realize the physical limitations that accompany this stage of life, such as a loss of attractiveness and vitality. These realizations can lead to a sense of rebellion against the changes that come with age.

In the face of these challenges, the author emphasizes the importance of qualities like fortitude, resignation, and philosophical acceptance over reliance on temporary solutions like medications. Embracing these virtues may provide more enduring support than any physical remedy.