In Samuel Beckett's "Waiting for Godot," the characters Estragon and Vladimir express a profound existential struggle. Estragon's assertion that he cannot continue reflects a deep sense of hopelessness and fatigue with their endless waiting. This interaction highlights the theme of despair, as they grapple with their purpose and the endless cycle of waiting for something—or someone—that may never arrive.

Vladimir's response, "That's what you think," suggests a complex interplay between resignation and action. It implies that despite Estragon's feelings of limitation, there is still a possibility for continuation, albeit uncertain and ambiguous. This exchange encapsulates the play's exploration of human existence, illustrating how individuals confront their circumstances in a world that often feels meaningless.