Nietzsche's assertion underscores the profound importance of embracing life and its fundamental aspects, including sexuality, without shame or moral judgment. In the modern context, societal taboos and moral conservatism often cast sexuality as something to be controlled, condemned, or sanitized, leading to the concept of impurity that alienates humans from their natural drives. Nietzsche challenges us to reconsider such notions, emphasizing that despising or impeding one's innate sexual energy is ultimately an attack on the vitality of life itself. This perspective aligns with his broader philosophy, which celebrates life-affirming instincts and criticizes those moral systems that impose guilt and repression. By framing the contempt for sex as a crime against life, Nietzsche invites reflection on how moral restrictions distort human nature and diminish our capacity to fully experience existence. According to him, genuine life-affirmation involves embracing all aspects of human experience, including our sexuality, without shame or deviations introduced by moral orthodoxy. The phrase "sine against the holy spirit of life" hints at a sacredness imbued in authentic vitality, which must remain untainted by negative judgments. Accepting this viewpoint can be empowering, for it pushes us to reject outdated shame-based notions, fostering a more honest, life-affirming approach to ourselves and others. Ultimately, Nietzsche urges a liberation from moral prejudices that suppress natural instincts, highlighting that such suppression is itself a moral crime that damages the essence of being alive.