The quote from Joyce Carol Oates' "Marya: A Life" reflects a profound sense of loss and the feeling that time is slipping away. It captures the essence of how life's moments, particularly those that define our experiences, can be taken from us without a chance to reclaim them. The imagery of "great handfuls" symbolizes the significant and irreplaceable parts of one's life that can vanish, leaving a void that is impossible to fill.

This sentiment evokes a deep emotional response, highlighting the fragility of life and the inevitability of change. It suggests that every moment is precious, and once lost, those experiences shape who we are but can never be revisited. Oates' exploration of this theme in Marya's life serves to remind readers of the importance of cherishing the present and valuing the time we have, as it is a finite resource that cannot be reclaimed once it slips away.