The quote "It's best not to mess with karma" suggests that one's actions have consequences, aligning with the philosophical notion that good or bad actions eventually come back to affect the individual. In Walter Isaacson's biography of Steve Jobs, this idea is reflected in Jobs' approach to life and business, where he believed that integrity and honesty play crucial roles in achieving success. Misleading practices or unethical behavior can lead to negative repercussions, as Jobs experienced throughout his journey.

This perspective on karma emphasizes the importance of personal responsibility and mindfulness in one's decisions. The book illustrates that Jobs, despite his brilliance, faced challenges due to his sometimes abrasive personality and controversial choices. Ultimately, the narrative implies that success is not just about innovation but also about maintaining a moral compass, reinforcing the idea that respecting the principles of karma can lead to a more fulfilling and impactful life.