In "Handle with Care," Jodi Picoult explores the legal profession's tendency to uncover cases that often seem improbable, yet have the potential for massive financial compensation. This notion highlights the opportunistic nature of some lawyers who may actively seek out situations that can lead to significant settlements or judgments. The pursuit of these cases can reflect both the tenacity and the sometimes controversial ethics within the field of law.

This theme underscores a broader commentary on the legal system, where the quest for lucrative cases can overshadow the fundamental principles of justice and morality. As lawyers navigate through unusual circumstances to find their next big case, the implications of their choices raise questions about the motivations driving the legal industry and the impact on those who become entwined in such legal battles.