In "The Adventure of the Cardboard Box," Holmes reflects on the pervasive violence and fear in the world, questioning the purpose behind such suffering. He expresses a profound concern about the nature of existence, suggesting that if there were no reason behind these events, it would imply a universe governed by randomness, which he finds unacceptable.

Holmes grapples with the enduring mystery of life’s meaning amid chaos. He acknowledges the complexity of human understanding and the challenges of uncovering a definitive answer to why misery exists. This contemplation highlights the struggle of human reason against the backdrop of inexplicable and often tragic circumstances.