The quote highlights the fundamental dissatisfaction that comes with being human. It suggests that no matter how much we achieve or experience, an underlying sense of unease persists. This is a universal aspect of human existence, influencing our thoughts and actions. Recognizing this can help people understand their emotional struggles and the quest for lasting happiness.

In "Mindfulness in Plain English," Gunaratana emphasizes the importance of mindfulness as a tool to navigate this natural discontent. By practicing mindfulness, individuals can learn to engage with their inner experiences more fully, rather than being overwhelmed by them. This practice fosters a greater awareness of the present moment, potentially alleviating the persistent feelings of dissatisfaction.