William Foege is a renowned American epidemiologist known for his significant contributions to global health. He played a pivotal role in the eradication of smallpox, developing strategies that became foundational for disease control worldwide. His work helped shape modern public health policies and emphasized the importance of vaccination and disease surveillance. Throughout his career, Foege has held various leadership positions, including director of the Centers for Disease Control and Prevention (CDC) and president of the Bill & Melinda Gates Foundation's Global Health Program. His efforts have focused on strengthening health systems and reducing infectious diseases, particularly in resource-limited settings. William Foege's innovative approach to public health has saved countless lives and continues to influence disease eradication programs. His leadership, research, and unwavering dedication to improving global health have made him a highly respected figure in the field. His work exemplifies the impact of strategic planning and committed action in combating infectious diseases around the world.