Fred Lowe Soper was a prominent American epidemiologist and public health leader known for his significant contributions to controlling infectious diseases. He specialized in malaria eradication, leading various programs in Latin America and Africa during the mid-20th century. Soper was particularly recognized for designing innovative field strategies and fostering collaboration between governments and international organizations to tackle public health challenges. His work went beyond malaria, as he was also involved in the campaigns against yellow fever and other infectious diseases. Soper's dedication to public health extended to his role in the establishment of the Pan American Health Organization, where he advocated for comprehensive approaches to health care and disease prevention. Soper's legacy is marked by his pragmatic approach to epidemiology and his ability to mobilize resources and expertise to fight against diseases that affected vulnerable populations. His efforts laid the groundwork for modern public health initiatives and highlighted the importance of sustained commitment to combating infectious diseases globally. Fred Lowe Soper was a notable American epidemiologist who played a crucial role in infectious disease control, particularly in malaria eradication efforts in Latin America and Africa. Known for his innovative strategies and collaboration with governmental and international entities, he significantly improved public health responses to tropical diseases. Through his leadership in establishing organizations like the Pan American Health Organization, Soper emphasized the importance of comprehensive public health approaches, leaving a lasting impact on global health initiatives.