Lester Grinspoon was a notable figure in the discourse around cannabis and its medicinal applications. He was a psychiatrist and an early advocate for the legalization of marijuana, entering the debate during a time when the substance was heavily stigmatized and largely prohibited. Grinspoon's pivotal work, "Marihuana: The Forbidden Medicine," published in 1993, highlighted the potential therapeutic benefits of cannabis, challenging long-held perceptions and encouraging further research into its medical uses. Grinspoon’s medical training equipped him to approach the subject with a scientific lens, allowing him to argue effectively for cannabis's ability to alleviate the symptoms of various conditions, such as cancer and multiple sclerosis. Over decades, he advocated fervently for drug policy reform, aiming to change both public opinion and legislation surrounding cannabis use. His work contributed significantly to the growing acceptance of cannabis as a legitimate form of treatment in modern medicine. Moreover, Grinspoon's influence extended into academia and public discussions, where he emphasized the importance of evidence-based research in assessing the drug's efficacy and safety. He remained a steadfast advocate for patient rights, ensuring that those who could benefit from cannabis for medicinal reasons were granted access. His legacy endures in the ongoing conversations about cannabis and its role in healthcare. Lester Grinspoon was a psychiatrist and a strong advocate for the legalization of cannabis, especially for its medicinal benefits. He authored influential works that shaped the dialogue around marijuana, particularly highlighting its therapeutic potential in treating various ailments. His book "Marihuana: The Forbidden Medicine" played a crucial role in changing perceptions of cannabis, emphasizing the need for more research and consideration of its medical applications. Grinspoon's efforts helped pave the way for a shift in policy and public opinion regarding marijuana. Through his advocacy and academic contributions, Grinspoon made a lasting impact on cannabis discourse. He championed patient access to cannabis treatment and emphasized the necessity of evidence-based research to support its use in medicine.